The Check Runway alert is issued when the aircraft attempts to takeoff from a runway that does not match the active flight plan. The system determines this when the Takeoff phase-of-flight is valid and the thrust levers are advanced while the aircraft is aligned with a runway that is not the departure runway entered in the active flight plan. Because it is somewhat common for ATC to redirect an aircraft to a different runway, this alert is a caution (amber) alert level as opposed to a warning (red) alert level.

In addition to the visual and voice alert, the Information Box contains a textual description of the currently occupied runway.